Respiratory mechanics and gas exchange in postobstructive pulmonary vasculopathy

Respiratory mechanics and gas exchange in postobstructive pulmonary vasculopathy.

Chronic unilateral pulmonary artery ligation induces formation of new bronchial collateral vessels in the affected lung. These vessels form precapillary anastomoses with the pulmonary circulation and the lung is perfused with arterial blood. Inspired gas is diverted to the contralateral lung to maintain the ventilation/perfusion ratio (VA/Q) and gas exchange. This study was designed to determin...

Respiratory Physiology: Gas Exchange and Respiratory Mechanics

Respiration provides oxygen (O2) and removes carbon dioxide (CO2) for the body. An extraordinary anatomic arrangement of functional units (the alveoli) delimited by extra-thin walls (epithelium and endothelium) creates the interface for gas exchange between air and blood. Repetitive expansion and collapse of the chest wall facilitates movement of gas in and out of the lungs. This review focuses...

Altered reactivity of pulmonary vessels in postobstructive pulmonary vasculopathy.

Chronic ligation of one pulmonary artery results in pulmonary vascular remodeling and bronchial angiogenesis, collectively known as postobstructive pulmonary vasculopathy (POPV). To investigate pulmonary vascular reactivity in POPV, we ligated the left main pulmonary artery of guinea pigs and, after 1-10 mo, prepared explants by inflating lungs with agarose and sectioning them into approximatel...

Changes in pulmonary mechanics and gas exchange following thoracocentesis.

In nine patients with large pleural effusions, we studied the changes in pulmonary mechanics and gas exchange that occurred in the first three hours following removal of 600 to 1,800 ml of fluid by thoracocentesis. There was a small but significant increase in the functional residual capacity and total lung capacity but no change in residual volume and vital capacity. Calculated pulmonary shunt...

Update on Respiratory Physiology: Pulmonary Gas Exchange